IMIM - Institut Hospital del Mar d'Investigacions Mèdiques IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

News

  • 15/09/2020 - Press release

    Decryption of a molecular code that regulates the behavior of the cells

    The research group of GPCR Drug Discovery at the Hospital del Mar Medical Research Institute (IMIM), in collaboration with the Indian Institute of Technology in Kanpur, has deciphered how nature adjusts the response of the human cell to abundant extracellular stimuli (e.g., smell, taste, light, hormones, etc.). When a cell receives an extracellular stimulus, it initiates a signaling process that can result in major physiological changes. This process is mediated by cell membrane proteins such as G protein coupled receptors (GPCRs). Depending on the stimulus, those receptors regulate cell activity through different molecular mechanisms.  Extracellular stimulation of GPCRs leads to its activation and subsequently to the phosphorylation of its long intracellular tail. Interestingly, there are multiple phosphorylation patterns of the receptor tail - each of them linked to a specific signaling response. The phosphorylation code is read by intracellular proteins known as β-arrestins. In response, they typically silence the receptor and modulate intracellular kinases, which have a global impact on cell behaviour related to gene expression, cell survival and cell death. "Until now, the phosphorylation code and the involvement of arrestins in deciphering it has been an open question" explains Dr. Selent. "We have discovered the underlying molecular mechanism of how arrestin reads and translates a specific phosphorylation pattern into a cellular response" she adds.

    Més informació "Decryption of a molecular code that regulates the behavior of the cells"

  • 03/09/2020 - Press release

    European grant of 1.5 million euros to study how the brain encodes and stores our experiences

    The European Research Council (ERC) has awarded Dr. Arnau Busquets García, a Ramón y Cajal researcher at the Hospital del Mar Medical Research Institute (IMIM), with a prestigious ERC Starting Grant. This recognition includes 1.5 million euros to develop a 5-year project. Grants from the ERC, which are part of the European Union's Horizon 2020 research and innovation program, are the main source of European funding for research excellence. They support highly innovative projects led by outstanding and internationally renowned researchers, with the aim of helping them to build their own teams and carry out pioneering research in Europe. In this year's edition, 3272 applications were submitted and 436 grants were awarded, for a total of 677 million euros. The recipients have 40 different nationalities and the projects will be developed in 25 different EU member states. The countries awarded the most grants are Germany (88 grants), the UK (62), the Netherlands (42), and France (38). Spain secured a total of 23 grants, 7 of which are going to Catalan research centers.

    Més informació "European grant of 1.5 million euros to study how the brain encodes and stores our experiences"

  • 18/08/2020 - Institutional news

    Nature Methods selects Jana Selent as the featured author of the month for August

    Dra. Jana Selent, coordinator of the GPCR drug discovery group, has been selected as the featured author of the month for the August edition in the journal Nature Methods. Recently, the Group of Dra. Selent published his latest article GPCRmd uncovers the dynamics of the 3D-GPCRome in this journal, where she presents a new tool to study one of the key elements in cell signaling, G protein-coupled receptors (GPCRs) which are the target of almost 40% of current drugs. This tool, the GPCRmd platform, will help improve our understanding of the function of these receptors, which are critical for transmitting signals to the interior of cells. The design of this tool has been made possible thanks to a consortium of researchers from 23 different institutions of 10 different European countries and the United States, led by the group of Dr. Jana Selent and with important contributions from researchers of the Paul Scherrer Institute (PSI) in Switzerland and the Autonomous University of Barcelona.

    Més informació "Nature Methods selects Jana Selent as the featured author of the month for August"

  • 17/08/2020 - Press release

    Dr. Marta Torrens and Dr. Rafael Maldonado edit a special issue of European Neuropsychopharmacology on the recreational use of cannabis

    The journal is dedicating a prominent position to research on cannabis and its derivatives, its recreational use, the associated risks, and potential medical applications. It features articles by some of the most prominent figures in the field, under the editorship of Dr. Torrens and Dr. Maldonado. The July issue of the journal European Neuropsychopharmacology is dedicating a special section to the controversy over the globally growing trend to legalise the use of marijuana for certain recreational and medical uses. This has been edited by Dr. Marta Torrens, director of the Addictions Process Group at the Hospital del Mar Institute of Neuropsychiatry and Addictions (INAD) and coordinator of the Addictions Research Group at the Hospital del Mar Medical Research Institute (IMIM), and Dr. Rafael Maldonado, head of the Neuropharmacology Laboratory at the Department of Experimental and Health Sciences (CEXS) at Pompeu Fabra University and the IMIM. Together they authored an editorial on the subject for the journal.

    Més informació "Dr. Marta Torrens and Dr. Rafael Maldonado edit a special issue of European Neuropsychopharmacology on the recreational use of cannabis"

  • 10/08/2020 - Press release

    COVID-19 hits hardest in the poorest areas of Barcelona

    The COVID-19 pandemic that, according to data from the Ministry of Health, has caused nearly 30,000 deaths in Spain, is hitting the most impoverished neighbourhoods the hardest, as confirmed by a study recently published in the Journal of Public Health and led by researchers from the Hospital del Mar Medical Research Institute (IMIM) and IDIAPJGol. The work reveals that, during the peak of the epidemic in the city of Barcelona, the district with the lowest average income, Nou Barris, recorded an incidence of cases 2.5 times higher than that of the district with the highest income, Sarrià-Sant Gervasi. The work took into account the incidence of cases recorded by age between 26 February and 19 April, one of the peak periods of the disease in Barcelona, and compared this with the average income data by district. In total, almost 9,000 cases were analysed. The results highlight a direct relationship between lower income and a higher number of COVID-19 cases.

    Més informació "COVID-19 hits hardest in the poorest areas of Barcelona"

  • 10/08/2020 - Press release

    FONDO SUPERA COVID-19 selects a study led by the Hospital de Mar Medical Research Institute, the Hospital del Mar and the University of Girona/IDIBGI, also involving the University of Vic and IDIAPJGol

    The project is one of 12 selected by the evaluation committee and will receive the second highest amount of money, 250,000 euros. The study, which involves the University of Girona, the University of Vic-Central-University of Catalonia and the Foundation for Higher Studies in Health Sciences, the Trueta and Santa Caterina hospitals and the University Institute for Primary Health Care Research (IDIAP-Jordi Gol), with the company Gen inCode and several healthcare centres in the United States also showing an interest, will analyse genetic predisposition to coronary risk as a prognostic element of severity in the event of contracting COVID-19. The CARGENCORS study, or CARdiovascular GENetic risk score for Risk Stratification of patients positive for the SARS-CoV-2 (COvid19) virus, was selected by the FONDO SUPERA COVID-19 (Beat COVID-19 Fund) evaluation committee, organised by the association of Spanish Universities (CRUE), the CSIC, and Santander Bank. With a pot of 8.5 million euros, the fund will finance projects in various fields with the aim of minimising the impact of the current pandemic, focusing on three priority areas: applied research, projects with social impact and profitability, and strengthening the ICT capacity of the state university system.

    Més informació "FONDO SUPERA COVID-19 selects a study led by the Hospital de Mar Medical Research Institute, the Hospital del Mar and the University of Girona/IDIBGI, also involving the University of Vic and IDIAPJGol"

  • 03/08/2020 - General information

    Two GRIB innovations developed in the framework of the eTRANSAFE project, acknowledged by the European Commission’s Innovation Radar

    The Innovation Radar, a European Commission initiative to identify high potential innovations and innovators in EU-funded research and innovation framework programmes, has selected two innovations developed by the GRIB in the project eTRANSAFE to be included on the Innovation Radar platform: Preclinical text mining solution for treatment response Advanced in silico modelling to predict toxicity These innovations, stemming from the project work, have been classified by the Innovation Radar as Exploring innovations in the early phases of technological readiness and have been published on the EU-funded innovations website on July 20th 2020, thus joining the 3600+ EU-funded innovations already showcased on the platform.

    Més informació "Two GRIB innovations developed in the framework of the eTRANSAFE project, acknowledged by the European Commission’s Innovation Radar"

  • 27/07/2020 - Press release

    World-Wide FINGERS: Spain is part of the first global initiative for prevention of dementia and Alzheimer´s disease

    World-Wide FINGERS (WW-FINGERS) is the first global network of clinical trials for risk reduction and prevention of dementia and Alzheimer´s disease through multidomain interventions. Spanish researchers from the Barcelonaβeta Brain Research Center (BBRC), the Hospital del Mar Medical Research Institute (IMIM) and the CITA Alzheimer Foundation participate in this network which convenes research teams from over 30 countries. The main scope, scientific strategy and activities of the WW-FINGERS network have been recently published in Alzheimer´s & Dementia. WW-FINGERS builds upon the successful experience of FINGER study: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, led by Prof. Miia Kivipelto and her team (Karolinska Institutet, Sweden; University of Eastern Finland; Finnish National Institute for Health and Welfare and Imperial College London, UK). This pioneering randomized clinical trial (RCT) demonstrated that a 2-year multidomain lifestyle intervention consisting of nutritional guidance, exercise, social stimulation, cognitive training, and control of vascular risk factors benefitted cognition in seniors at increased risk of dementia (Lancet 2015). 

    Més informació "World-Wide FINGERS: Spain is part of the first global initiative for prevention of dementia and Alzheimer´s disease"

  • 28/07/2020 - General information

    Hospital del Mar and GRIB take part in the EHDEN Pilot and EHDEN COVID-19 Rapid Collaboration projects

    The main goal of the European project EHDEN: European Health Data & Evidence Network, is to carry out large-scale analysis of European clinical data (Real-World Clinical Data), using bioinformatics tools and standards based on the international OHDSI initiative and the OMOP common date model (CDM). EHDEN will speed up studies and research related to characterising patients with COVID-19 and other diseases, and evaluate the best treatments and clinical management for these patients, using millions of clinical records from all over Europe.

    Més informació "Hospital del Mar and GRIB take part in the EHDEN Pilot and EHDEN COVID-19 Rapid Collaboration projects"

  • 24/07/2020 - Institutional news

    IMIM, one of the Health Research Institutes to receive an ISCIII Responsible Research and Innovation Award

    In the first edition of the Responsible Research and Innovation (RRI) in Health Awards organised by ISCIII and promoted as part of the European project ORION  (Open Responsible research and Innovation to further Outstanding kNowledge) three proposals from three different Health Research Institutes (HRI) have been honoured out of a total of 26 proposals received. One of these three proposals is an IMIM project: The name of the successful project is "Co-creation and citizen participation in the design of the PENSA Study on the Prevention of Cognitive Impairment in People with Subjective Memory Complaints". Presented by Natàlia Soldevila and Laura Forcano from the Integrated Pharmacology and Systems Neuroscience research group at the IMIM, this work stands out for its application of citizen participation in the design of a clinical trial, an added value that allows the project to be reoriented to better adapt to the needs and expectations of the participants.

    Més informació "IMIM, one of the Health Research Institutes to receive an ISCIII Responsible Research and Innovation Award"

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Marta Calsina(ELIMINAR)

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