Cellular and Systems Neurobiology
The Cellular and Systems Neurobiology group is a CRG (Centre for Genomic Regulation) research group associated with IMIM. Our overall goal is to understand how the neuronal architecture and connectivity constrain the mesoscopic network activity and influences the flow and storage of information in neuronal circuits. Alterations in the architectural properties of the neurons are observed in most mental disorders and are assumed to be the cause of the cognitive disturbances. We focus mainly on intellectual disability and neuropsychiatric disorders, using a systems neuroscience approach that combines behavioral, computational and neurobiological analyses in mice, with the results from cellular models. Based on our understanding of the genetic and molecular circuits disturbed in intellectual disability we have participated in several clinical trial in Down syndrome (De la Torre et al, 2016) and fragile X syndrome (FRAXA Foundation).
Main Publications with IMIM
• Faundez V, De Toma I, Bardoni B, Bartesaghi R, Nizetic D, de la Torre R, Cohen Kadosh, Herault Y, Dierssen M, Potier MC, Down Syndrome and Other Genetic Developmental Disorders ECNP Network. Translating molecular advances in Down syndrome and Fragile X syndrome into therapies. Eur Neuropsychopharmacol 2018; 28(6): 675-690. IF 4.129. Q1.
• Manubens L. Computational and modelling approaches to multi-scale anatomical description of neuronal circuitry. Universitat Pompeu Fabra.
- Directors: Dierssen, Mara; García, J.
- Date of defense: 18/01/2018
• Ortega M. Elucidation of disease-related protein networks underlying Dyrkia triplication and pro-cognitive therapies in the lippocampus. Universitat Pompeu Fabra.
- Directors: Dierssen, Mara; Sabidó, Eduard
- Date of defense 23/01/2018