Molecular Mechanisms of Cancer and Stemness

Research group

Group Leader

Lluís Espinosa Blay

The Molecular Mechanisms of Cancer and Stemness group is fully dedicated to the identification of elements and pathways that regulate Stem Cell and Cancer Stem Cell homeostasis, with the final goal of discovering biomarkers and therapeutic targets for regenerative medicine and cancer.

The group has historically focused on studying the Notch and NF-κB pathways, which are principal actors of these processes. However, our research now aims to integrate these pathways in the context of other important signals for stem cell and cell transformation such as BRAF or ß-catenin.




Juan Bertran Comulada (Researcher)

Carlota Colomer Montañá (PhD Student)

Laura Marruecos Aylagas (PhD Student)

Laura Solé Font (Technician)



Main Publications

• Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell 2017; 32(5): 608-623. IF 27.407. D1.

Ongoing Research Projects

• Identificación de nuevos biomarcadores y dianas terapéuticas asociados a la actividad IKK

- Fondo de Investigación Sanitaria. ISCIII (PI16/00437)

- From 2017 to 2019

- Principal investigator: Espinosa Blay, Lluís

• Nuclear active IKKa as biomarker and new therapeutic target for Colorectal Cancer

- Fundació la Marató de TV3 (20131210)

- From 2014 to 2017

- Principal investigator: Espinosa Blay, Lluís



• Colomer C. Unravelling new oncogenic functions of IKKα:towards a better understanding of colorectal carcinogenesis. Pompeu Fabra University

- Directors: Espinosa Blay, Lluís; Bigas Salvans, Anna.

- Date of defense: 21/12/2017




C/ Doctor Aiguader, 88

08003 Barcelona

(+34) 93 316 04 00