2016
Group Leader
Gabriel Gil Gómez
Dysregulation of DNA damage repair and signalling to cell cycle checkpoints is associated with a predisposition to cancer and affects responses to DNA-damaging anticancer therapy. We describe the role of Cyclin O in the regulation of DNA damage repair and in the activation of the cellular DNA damage checkpoints. Cyclin O is also a crucial regulator of the generation of multiciliated cells through modulation of the activity of the ciliogenic transcription factors FoxJ1 and Myb. It is also necessary for deuterosome-mediated centriole amplification and for apical docking of the basal bodies, the cilia-anchoring structures. Most human tumors show overexpression of Cyclin O. In vitro modification of cellular levels of Cyclin O leads to the generation of aberrant mitotic spindles due to centrosome amplification. Our working hypothesis assumes that expression of Cyclin O in non-ciliated cells leads to deuterosome-mediated centriole amplification and consequent multipolar, aberrant mitotic spindle formation. Cyclin O expression in epithelial cells that have acquired a preneoplastic lesion as a consequence of the activation of the DNA damage response may be linked to the appearance of aneuploidy and genomic instability.
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Main Publications
• Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanovic M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH. GEMC1 is a critical regulator of multiciliated cell differentiation. Embo J 2016; 35(9): 942-960. IF 9.643. Q1.
Ongoing Research Projects
• Autoinmunidad, inflamación y cáncer: el papel mediador de la Ciclina O y su posible aplicación clínica como indicador temprano de transformación tumoral
− Fondo de Investigación Sanitaria. ISCIII (PI13/00864)
− From 2014 to 2017
− Principal investigator: Gil Gómez, Gabriel
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca Apoptosi, autoimmunitat i transformació epitelial (2014-2017)
− Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 136)
− Principal investigator: Gil Gómez, Gabriel
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