IMIM - Institut Hospital del Mar d'Investigacions Mèdiques IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

PuigLab - Research lines

  • Study of the cellular mechanisms underlying the modulation of neural network activity and the communication between different brain regions by the serotonergic system during executive function.
  • Deepen our understanding about the cellular mechanisms underlying the actions of typical (1st generation) and atypical (2nd generation) antipsychotics during cognitive processes. More specifically, we compare how the two treatments modulate neural network activity and the communication between different brain regions.
  • Study of the neural substrates underlying the deficits in executive function present in murine models of intellectual disability. More specifically:
    • Describe the anomalies present in the frontohipocampal circuit in two mouse models of Down syndrome: mice with partial trisomy of chromosome 16 (Ts65Dn, the equivalent of chromosome 21 in humans) and transgenic mice overexpressing DYRK1A (TgDyrk1A) during learning and memory tasks.
    • Examine the possible beneficial effects of the DYRK1A inhibitor EGCG (epigallocatechin-3-gallate) on this circuit. In collaboration with the laboratory of Prof. Mara Dierssen (Center for Genomic Regulation, Barcelona).

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