IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Computational Biology of RNA Processing Roderic Guigó

Genomic technologies are generating an extraordinary amount of information, unprecedented in the history of Biology. Thus, a new scientific discipline, Bioinformatics, at the intersection between Biology and Computation, has recently emerged. Bioinformatics addresses the specific needs in data acquisition, storage, analysis and integration that research in genomics generates.

The computational genomics research group is a CRG (Centre for Genomic Regulation) research group that is associated with the IMIM. Within the CRG, Bioinformatics plays a role central to the other research programs at the CRG. Among the current research lines, we highlight

  1. Gene Prediction and Modeling of Splicing, related to the research on Regulation of Alternative Splicing, and on Regulation of Protein Synthesis within the "Gene Regulation" program, and in general with the "Genes and Diseases" program,
  2. Identification and characterization of genomic regions involved in Gene Regulation, related to the research on Chromatin and Gene Expression, and on RNA proteins Interactions within the "Gene Regulation" program, and
  3. Molecular Evolution, which includes evolution of the exonic structure of the genes, and evolution of splicing.

The "Bioinformatics" program also includes a research group in microarrays, which will be complemented soon with a new group specifically devoted to Microarray Informatics. The "Bioinformatics" program is closely related to the Research Group in Biomedical Informatics (GRIB) at the IMIM-UPF.

Whitin the GRIB, a number of complementary research lines are being developed in Molecular Modeling, Protein Structure Prediction, and Complex Systems. We believe that the coexistence at the IMIM-UPF-CRG of these diverse groups in Computational Biology (unique in Spain), will facilitate a global understanding of the living cell, from the recognition of specific signals in the DNA sequence to the elucidation of the complex protein interaction network.


Roderic Guigó

93 316 02 37

93 316 04 10

Dr. Aiguader, 88
08003 Barcelona

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