Clinical Illness


Inflammatory and Cardiovascular Disorders Programme

Group Leader

Joan Ramon Masclans Enviz

The Critical Illness Research Group (GREPAC) aims to elucidate the mechanisms involved in the onset and progression of different illnesses that cause a reversible dysfunction in one or more organs, placing the patient’s life at risk. Our research includes clinical research in patients, and also experimental models which allow us to study the molecular mechanisms involved in these processes and to identify therapeutic targets and new strategies.

GREPAC understands Critical Care research from a translational, clinical, and multi-disciplinary perspective; therefore GREPAC conducts controlled clinical trials and observational projects of great interest, participating at all possible levels of commitment: as promoters, lead researchers and collaborators in multi-centre projects, as well as developing our own projects.

The research group was recognized by AGAUR (Agència de Gestió d’Ajuts Universitaris i de Recerca, Generalitat de Catalunya) as a research group  2017-2020: Grup de Recerca en Patologia Crítica (SGR 200; Principal investigator: Judith Marín Corral).

 Research group


Francisco Álvarez Lerma (Researcher)

Yolanda Díaz Buendía (Researcher)

María Pilar Gracía Arnillas (Researcher)

Judith Marín Corral (Researcher)

Purificación Pérez Terán (Researcher)

Anna Salazar Degracia (Researcher)

Antonia Vázquez Sánchez (Researcher)

Clara Vilà Vilardell (Researcher)

Ana Zapatero Ferrandiz (Researcher)

Irene Dot Jordana (PhD Student)

Ana Alabart Llinàs (Technician)

Thais Guri López (Technician)

Rosana Muñoz Bermúdez (Technician)

Francisco José Parrilla Gómez (Technician)

Marta Gas Amat (Research Assistant)


Main PublicationsOngoing Research ProjectsParticipation in Research NetworksClinical Trials Signed in 2019ThesesAppointmentsOutreach 


Main Publications

• Subirà C, Hernández G, Vázquez-Sánchez A, Rodríguez-García R, González-Castro A, García C, Rubio O, Ventura L, López A, de la Torre MC, Keough E, Arauzo V, Hermosa C, Sánchez C, Tizón A, Tenza E, Laborda C, Cabañes S, Lacueva V, Fernández MM, Arnau A, Fernández R. Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA 2019; 321(22): 2175-2182. IF 51.273. D1.

• Marín J, Dot I, Boguña M, Cecchini L, Zapatero A, Gracía-Arnillas MP, Pascual S, Vilà C, Castellví A, Pérez-Terán P, Gea J, Masclans JR. Structural differences in the diaphragm of patients following controlled vs assisted and spontaneous mechanical ventilation. Int Care Med 2019; 45(4): 488-500. IF 18.967. D1.

• Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, García-de-Acilu M, Frat JP, Masclans JR, Ricard JD. An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High Flow Therapy. Am J Respir Crit Care Med 2019; 199(11): 1368-1376. IF 16.494. D1.

• Fernández-Barat L, Motos A, Panigada M, Álvarez-Lerma F, Viña L, López-Aladid R, Ceccato A, Bassi GL, Nicolau DP, López Y, Muñoz L, Guerrero L, Soy D, Israel T, Castro P, Torres A. Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients. Crit Care 2019; 23(1): 251. IF 6.959. Q1.

• Luque S, Hope W, Campillo N, Muñoz-Bermúdez R, Sorli L, Barceló-Vidal J, González E, Álvarez-Lerma F, Masclans JR, Montero M, Horcajada JP, Grau S. Population pharmacokinetics of anidulafungin in critically ill patients. Antimicrob Agents Chemother 2019; 63(7): e00378-19. IF 4.715. Q1.

   See all Publications

Ongoing Research Projects

• Papel del eje IL-33 /ST2 en el diagnóstico, pronóstico y tratamiento del Síndrome de distrés respiratorio agudo

- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI14/01420)

- Period: from 2015 to 2019

- Principal investigator: Masclans Enviz, Joan Ramon

• Mecanismos moleculares de disfunción diafragmática asociada a ventilación mecánica (VIDD) tras la utilización de modalidades ventilatorias controladas y espontáneas en un modelo humano

- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI18/000025)

- Period: from 2019 to 2021

- Principal investigator: Marín Corral, Judith; Masclans Enviz, Joan Ramon

• Efecto de la ceftarolina sobre la respuesta immunomoduladora y anti-inflamatoria en un modelo murino de neumonía neumocócica

- Financing institution: Sociedad Española de Neumología y Cirugía Torácica (SEPAR)

- Period: from 2019 to 2022

- Principal investigator: Marín Corral, Judith

   See all Projects


Participation in Research Networks

• CIBERES: Ciber of Respiratory Diseases

• HISPAFLOW: Spanish Group of Experts in High Flow Oxygen Therapy

• Acute Respiratory Failure – Section Translational Biology Group of the European Society of Intensive Care Medicine (ESICM)

• GETGAG: Spanish Working Group in Severe Influenza A

• GLIMP: Global Initiative for MRSA Pneumonia


Clinical Trials Signed in 2019

• La oxigenoterapia de alto flujo como adyuvante en el tratamiento de la sepsis grave

- Protocol: ALT-OXI-2018

- Sponsor: Althaia Xarxa Assistencial de Manresa Fundació Privada

- Budget: No economic compensation

- Principal investigator: Masclans Enviz, Joan

• A Randomized, Active-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-Calcoaceticus Complex

- Protocol: CS2514-2017-0004

- Sponsor: Entasis Therapeutics

- Budget: 28,730 €/patient (no patients included)

- Principal investigator: Vázquez Sánchez, Antonia

• Randomized, embedded, multifactorial adaptive platform trial for Community-acquired pneumonia

- Protocol: REMAP-CAP

- Sponsor: UMC Utrecht

- Budget:  300 €/patient (1 patient included)

- Principal investigator: Muñoz Bermúdez, Rosana



• Díaz Y. “UCI extendida” seguimiento de los pacientes críticos al alta del Servicio de Medicina Intensiva del Hospital del Mar. Universitat Autònoma de Barcelona

- Director: Sancho Insenser, Joan Josep; Navarro Soto, Salvador; Masclans Enviz, Joan Ramon

- Date of defense: 27/11/2019



• Joan Ramon Masclans. Teaching Director of the PSMAR. February 2019.

• Joan Ramon Masclans. Member of the Research Commission of the PSMAR. 2019.

• Joan Ramon Masclans. Member of the Governing Board of the PSMAR. 2019.

• Joan Ramon Masclans. President of the Comissió d’aturades of the PSMAR. 2019.

• Joan Ramon Masclans. Secretary of the Organ and Tissue Donation and Transplant Commission

• Recognition by the AQU of two research sections (six years). 5 July 2019.



Dissemination to Society and Initiatives of Citizen Participation

• Judith Marín Corral. Round table on the scientific career. BioJunior. 3 May 2019.

• Judith Marín Corral, Rosana Muñoz. Student of the Font del Ferro Institute visit the Laboratory of the Critical Illness Research Group. ACCÉS Project (Bringing Science Closer to Secondary Schools) included in the Escolab Project. Barcelona Science Programme of the Institute of Culture. 1 March 2019.

• Judith Marín Corral. Talk at the Institut La Salle Barceloneta. International Day of Women and Girls in Science. 11 February 2019.

• Rosana Muñoz, Anna Salazar, Purificación Pérez, Irene Dot. Visit to the Laboratory of the Critical Illness Research Group. Open Day of the Parc de Recerca Biomèdica de Barcelona (PRBB), 5 October 2019.

• Ana Zapatero. Donor’s Day event. Palau Robert, Barcelona. 4 June 2019.

• Judith Marín Corral. Jornada “Posant el pacient en el centre de la recerca”. 21 January 2019.









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