Research group

Group Leader

Jaume Roquer González

This is a clinical group involved in stroke research. Currently our group is included in the Red de Enfermedades Vasculares Cerebrales (INVICTUS PLUS) that is one of the main Spanish research networks. The strengths of our group are: first, our ongoing database named BASICMAR, that contains extensive demographic, epidemiological, clinical, and outcome data about all stroke patients (n=8,300) admitted to our hospital, and second, our large collection of blood sample of stroke patients for genetic and biomarkers studies (n=6,000). The two main research lines are:

1. Clinical research and biomarkers in stroke: epidemiology, natural history and vascular risk factors, stroke biomarkers, environmental and stroke,  diet and stroke, neurosonology and neuro-imaging.

2. Genetic and stroke research: our unit is part of the International Stroke Genetics Consortium, which includes many international (USA, Europe) and national groups and of the GENESTROKE Consortium working to develop GWAS and EWAS studies and projects.


Elisa Cuadrado Godia (Researcher)

Jordi Jiménez Conde (Researcher)

Ángel Javier Ois Santiago (Researcher)

Ana María Rodríguez Campello (Researcher)

Carolina Soriano Tárraga (Researcher)

Carla Avellaneda Gómez (Technician)

Uxue Lazcano Dobao (Technician)

Gemma Romeral Ballester (Technician)

Miguel Ángel Rubio Pérez (Technician)

Rosa Maria Vivanco Hidalgo (Technician)


Main Publications

• Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet 2018; 50(4): 524-537. IF 27.125. D1.

• Ois A, Zabalza A, Moreira A, Cuadrado E, Jiménez-Conde J, Giralt E, Rodríguez-Campello A, Soriano C, Roquer J. Long-term cardiovascular prognosis after transient ischemic attack: Associated predictors. Neurology 2018; 90(7): e553-e558. IF 7.609. D1.

• Marini S, Devan WJ, Radmanesh F, Miyares L, Poterba T, Hansen BM, Norrving B, Jiménez-Conde J, Giralt E, Elosua R, et al. 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage. Stroke 2018; 49(7): 1618-1625. IF 6.239. D1.

• Ntaios G, Lip GYH, Lambrou D, Michel P, Perlepe K, Eskandari A, Nannoni S, Sirimarco G, Strambo D, Vemmos K, et al. Renal Function and Risk Stratification of Patients With Embolic Stroke of Undetermined Source. Stroke 2018; 49(12): 2904-2909. IF 6.239. D1.

• Cuadrado E, Dwivedi P, Sharma S, Ois A, Roquer J, Balcells M, Laird J, Turk M, Suri HS, Nicolaides A, Saba L, Khanna NN, Suri JS. Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies. J Stroke 2018; 20: 302-320. IF 4.75. Q1.

• Vivanco R, Wellenius G, Basagaña X, Cirach M, Gómez-González A, de Ceballos P, Zabalza A, Jiménez-Conde J, Soriano C, Giralt E, Alastuey A, Querol X, Sunyer J, Roquer J. Short-term exposure to traffic-related air pollution and ischemic stroke onset in Barcelona, Spain. Environ Res 2018; 162: 160-165. IF 4.732. D1.

• Avellaneda-Gómez, C C, Serra-Martínez M, Rodríguez-Campello A, Ois A, Cuadrado E, Giralt E, Vivanco R, Jiménez-Conde J, Gómez-González A, de Ceballos P, Zabalza A, Mola M, Soriano C, Roquer J. Alcohol overuse and intracerebral hemorrhage: Characteristics and long-term outcome. Eur J Neurol 2018; 25(11): 1358-1364. IF 4.621. Q1.

• Giralt E, Medrano-Martorell S, Soriano C, Mola M, Rasal R, Cuadrado E, Rodríguez-Campello A, Ois A, Capellades J, Jiménez-Conde J, Roquer J. Brainstem leukoaraiosis independently predicts poor outcome after ischemic stroke. Eur J Neurol 2018; 25(8): 1086-1092. IF 4.621. Q1.

• Roquer J, Vivanco R, Capellades J, Ois A, Cuadrado E, Giralt E, Soriano C, Mola M, Serra M, Avellaneda-Gómez C, Jiménez-Conde J, Rodríguez-Campello A. Ultra-early hematoma growth in antithrombotic pretreated patients with intracerebral hemorrhage. Eur J Neurol 2018; 25(1): 83-89. IF 4.621. Q1.

• Soriano C, Giralt E, Mola M, Ois A, Rodríguez-Campello A, Cuadrado E, Fernández-Cadenas I, Cullell N, Roquer J, Jiménez-Conde J. Biological Age is a predictor of mortality in Ischemic Stroke. Sci Rep 2018; 8(1): 4148. IF 4.122. Q1.

Ongoing Research Projects

• The Chemical Optimization of Cerebral Embolectomy (CHOICE) Trial

- Financing institution: Fundació La Marató de TV3 (20170732)

- Period: from 2018 to 2021

- Principal investigator: Cuadrado Godia, Elisa

• Impacto de la polución ambiental aérea (carbón negro y material particulado) en el ictus isquémico

- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI15/00445)

- Period: from 2016 to 2019

- Principal investigator: Roquer González, Jaume

• Estudio de Epigenome Wide Association en Leucoaraiosis. Contribución de la epigenética en el envejecimiento cerebral. International Stroke Genetic Consortium (ISGC)

- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI15/00451)

- Period: from 2016 to 2019

- Principal investigator: Jiménez Conde, Jordi


Participation in Research Networks

• Red de Enfermedades Vasculares Cerebrales. INVICTUS PLUS

- Fondo de Investigación Sanitaria-ISCIII. Subprograma RETICS (RD16/0019/0002)

- Principal investigator: Roquer González, Jaume


Group’s Recognitions

• Officially recognized as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca Neurovascular (NEUVAS) (2017-2020)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 28)

- Principal investitgator: Roquer González, Jaume


Clinical Trials Signed in 2018

• Estudio internacional, multicéntrico, abierto y de grupos paralelos, para evaluar la eficacia en la reducción de cLDL y presión arterial y la seguridad de la polipildora cardiovascular Fuster-CNIC-Ferrer versus tratamiento habitual en pacientes con enfermedad cardiovascular aterotrombótica. Estudio APOLO

- Register: FMD-TRI-2017-01

- Principal investigator: Rodríguez Campello, Ana María

• Optimización química de la embolectomía cerebral en pacientes con un ictus agudo tratados con trombectomía mecánica (ESTUDIO CHOICE)

- Register: CHOICE

- Principal investigator: Cuadrado Godia, Elisa

• Estudio en fase III, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos para evaluar la eficacia y la seguridad de BIIB093 por vía intravenosa (glibenclamida) para el edema cerebral grave tras infarto hemisférico maligno

- Register: 252LH301

- Principal investigator: Rodríguez Campello, Ana María










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08003 Barcelona

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