Critical Illness

 Research group

Group Leader

Joan Ramon Masclans Enviz

The Critical Illness Research Group (GREPAC) aims at contributing to elucidate the mechanism involved in the onset and progression of different illnesses that cause a reversible dysfunction to one or more organs placing the patient’s life at risk. To do this, our research includes clinical research on patients, and also experimental models. These models allow us to study the molecular mechanisms involved in these processes and to identify therapeutic targets and new strategies against these illnesses and, whenever possible, to anticipate ourselves to these cascades to avoid more illnesses and multi-organ dysfunction.

The Critical Illness Research Group conceived Intensive Medicine research from a translational, clinical and multi-disciplinary approach; hence, another important objective is to further study new strategies and treatments by conducting controlled clinical trials and observational projects with a high interest, participating at all possible levels of commitment: as promoters, lead researchers, collaborators in multi-center projects and developing our own projects.



Francisco Álvarez Lerma (Researcher)

Maria Cristina Climent Company (Researcher)

Yolanda Díaz Buendía (Researcher)

María Pilar Gracia Arnillas (Researcher)

Judith Marín Corral (Researcher)

Joan Nolla Salas (Researcher)

Purificación Pérez Terán (Researcher)

Sara Vallés Angulo (Researcher)

Antonia Vázquez Sánchez (Researcher)

Clara Vilà Vilardell (Researcher)

Ana Zapatero Ferrándiz (Researcher)

Ana Alabart Llinàs (Technician)

Irene Dot Jordana (Technician)

Thais Guri López (Technician)

Rosana Muñoz Bermúdez (Technician)

Marta Gas Amat (Research Assistant)


Main Publications

• Collet MO, Caballero J, Sonneville R, Bozza FA, Nydahl P, Schandl A, Wøien H, Citerio G, van den Boogaard M, Hästbacka J, Haenggi M, Colpaert K, Rose L, Barbateskovic M, Lange T, Jensen A, Krog MB, Egerod I, Nibro HL, Wetterslev J, Perner A, AID-ICU cohort study co-authors (...Masclans JR, Marín J...). Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Int Care Med 2018; 44(7): 1081-1089. IF 15.008. D1.

• Moreno G, Rodríguez A, Reyes LF, Gómez J, Solé-Violan J, Díaz E, Bodí M, Trefler S, Guardiola J, Yébenes JC, Soriano A, Garnacho-Montero J, Socias L, Del Valle Ortíz M, Correig E, Marín J, Vallverdú-Vidal M, Restrepo MI, Torres A, Martín-Loeches I, on Behalf GETGAG Study Group. Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study. Int Care Med 2018; 44(9): 1470-1482. IF 15.008. D1.

• Vincent JL, Lefrant JY, Kotfis K, Nanchal R, Martín-Loeches I, Wittebole X, Sakka SG, Pickkers P, Moreno R, Sakr Y, SOAP investigators (...Álvarez-Lerma F...). Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP). Int Care Med 2018; 44(3): 337-344. IF 15.008. D1.

• Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martín-Loeches I, Almirall J, et al. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). Int Care Med 2018; 44(4): 438-448. IF 15.008. D1.

• Álvarez-Lerma F, Palomar-Martínez M, Sánchez-García M, Martínez-Alonso M, Álvarez-Rodríguez J, Lorente L, Arias-Rivera S, García R, Gordo F, Añón JM, Jam-Gatell R, Vázquez-Calatayud M, Agra Y. Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU "Pneumonia Zero" Program. Crit Care Med 2018; 46(2): 181-188. IF 6.63. Q1.

• Álvarez-Lerma F, Grau S, Echeverría-Esnal D, Martínez-Alonso M, Gracia-Arnillas MP, Horcajada JP, Masclans JR. A Before-and-After Study of the Effectiveness of an Antimicrobial Stewardship Program in Critical Care. Antimicrob Agents Chemother 2018; 62(4): e01825-17. IF 4.255. Q1.

• Álvarez-Lerma F, Olaechea-Astigarraga P, Palomar-Martínez M, Catalán M, Nuvials X, Gimeno-Costa R, Gracia-Arnillas MP, Seijas-Betolaza I, ENVIN-HELICS Study Group. Invasive device-associated infections caused by Pseudomonas aeruginosa in critically ill patients: evolution over 10 years. J Hosp Infect 2018; 100(3): e204-e208. IF 3.354. Q1.

• Hazard D, Schumacher M, Palomar-Martínez M, Álvarez-Lerma F, Olaechea-Astigarraga P, Wolkewitz M. Improving nested case-control studies to conduct a full competing-risks analysis for nosocomial infections. Infect Control Hosp Epidemiol 2018; 39(10): 1196-1201. IF 3.084. Q1.

• Wolkewitz M, Mandel M, Palomar-Martínez M, Álvarez-Lerma F, Olaechea-Astigarraga P, Schumacher M. Methodological challenges in using point-prevalence versus cohort data in risk factor analyses of nosocomial infections. Ann Epidemiol 2018; 28(7): 475-480.e1. IF 2.804. Q1.

Ongoing Research Projects

• Mecanismos moleculares de disfunción muscular respiratoria tras la utilización de diferentes estrategias de ventilación mecánica

- Financing institution: Fundación Española de Enfermo Crítico

- Period: from 2017 to 2019

- Principal investigator: Marín Corral, Judith; CoIP: Masclans Enviz, Joan Ramon

• Papel del eje IL-33 /ST2 en el diagnóstico, pronóstico y tratamiento del síndrome de distrés respiratorio agudo

- Financing institution: Fondo de Investigación Sanitaria. ISCIII (PI14/01420)

- Period: from 2015 to 2019

- Principal investigator: Masclans Enviz, Joan Ramon

• Estudio multicéntrico del impacto del microbioma respiratorio y gastrointestinal en el pronóstico de los pacientes críticos

- Financing institution: Sociedad Española de Neumología y Cirugía Torácica (SEPAR)

- Period: from 2018 to 2021

- Principal investigator: Marín Corral, Judith


Participation in Research Networks

• CIBERES: CIBER of Respiratory Diseases

• CISA: Ibero-American cooperation in high flow support

• HISPAFLOW: Spanish group of experts in high flow oxygen therapy

• Acute Respiratory Failure, Section Translational Biology Group (European Society of Intensive Care Medicine, ESICM)

• Acute Respiratory Failure, Spanish Critical Care Society (SEMICYUC)

• GETGAG: Spanish Working Group in Severe Influenza A


Group’s Recognitions

• Officially recognized as an emerging research group by the Generalitat de Catalunya: Grup de Recerca en Patologia Crítica (GREPAC) (2017-2020)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 200)

- Principal investigator: Marín Corral, Judith


Clinical Trials Signed in 2018

• Estudio de fase III, aleatorizado, doble ciego, controlado con placebo, multicéntrico para evaluar la eficacia y seguridad de baloxavir marboxil en combinación con el tratamiento estándar inhibidor de neuraminidasa en pacientes hospitalizados con influenza grave

- Register: CP40617

- Principal investigator: Marín Corral, Judith

• A randomized, double-blind, multi-center study to stablish the efficacy and safety of ceftobiprole medocaril compared to daptomycin in the treatment of Staphylococcus aureus bacteremia, including infective endocarditis

- Register: BPR-CS-009

- Principal investigator: Marín Corral, Judith



• Antònia Vàzquez. Golpe de calor. Experiencia en el Hospital del Mar de Barcelona. Estudio clínico-epidemiológico, de mediadores inflamatorios y hemostasia. Universitat Autònoma de Barcelona.

- Director: Masclans, Joan Ramon; Nolla, Joan

- Date of defense: 20/11/2018



• Grant for the training in foreign research centers of the specialized medical staff of the Parc de Salut Mar

- Hospital del Mar

- Principal investigator: Marín Corral, Judith

• Impact of antibiotic treatment and its plasma levels on the respiratory and intestinal microbiomy of patients with severe community pneumonia. Jordi Gras Research Grant 2018 for residents of the Parc de Salut MAR

- Parc de Salut MAR

- Principal researcher: Muñoz Bermúdez, Rosana

• Fisher & Paykel scholarship for personnel financing

- Fisher & Paykel

- Principal investigator: Masclans Enviz, Joan Ramon









C/ Doctor Aiguader, 88

08003 Barcelona

(+34) 93 316 04 00