Translational Research on Hematological Neoplasms

Research group

Group Leader

Blanca Espinet Solà

The Translational Research on Hematological Neoplasms Group (GRETNHE) is integrated within the Cancer Programme from the Hospital del Mar Medical Research Institute (IMIM). The GRETNHE is a multidisciplinary group with different research areas. Among them, the most relevant are myelodysplastic syndromes (MDS), myeloproliferative neoplasms/myelodysplastic syndromes (MPN/MDS), chronic lymphocytic leukemia/monoclonal B cell lymphocytosis (CLL/MBL), mantle cell lymphoma/monoclonal asymptomatic lymphocytosis cyclin D1 positive (MCL/MALD1), splenic marginal zone lymphoma (SMZL) and cutaneous lymphomas (CL). Our aim is the phenotypic, cytogenetic and molecular characterization of these entities

 

2017

Members

Leonor Arenillas Rocha (Researcher)

Luis Carlos Barranco Sanz (Researcher)

Xavier Calvo González (Researcher)

Lluís Colomo Saperas (Researcher)

Ana Ferrer del Álamo (Researcher)

Fernando Gallardo Hernández (Researcher)

Carme Pedro OIivé (Researcher)

Anna Maria Puiggros Metje (Researcher)

Marta Salido Galeote (Researcher)

Sergi Clavé Safont (Technician)

Beatriz Costán Medina (Technician)

M. Carme Melero Vilella (Technician)

Maria del Mar Rodríguez Rivera (Technician)

 

 

Main Publications

• Arenillas L, Calvo X, Sanz GF, Florensa L. Reply to MA Lichtman. J Clin Oncol 2017; 35(12): 1376-1377. IF 24.008. D1.

• Granell M, Calvo X, García-Guiñón A, Escoda L, Abella E, Martínez CM, Teixidó M, Giménez MT, Senín A, Sanz P, Campoy D, Vicent A, Arenillas L, Rosiñol L, Sierra J, Blade J, Fernández de Larrea C. Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukaemia definition. Haematologica 2017; 102(6): 1099-1104. IF 7.702. D1.

• Collado R, Puiggros A, López-Guerrero JA, Calasanz MJ, Larrayoz MJ, Ivars D, García-Casado Z, Abella E, Orero MT, Talavera E, Oliveira AC, Hernández-Rivas JM, Hernández-Sánchez M, Luño E, Valiente A, Grau J, Portal I, Gardella S, Salgado AC, Giménez MT, Ardanaz MT, Campeny A, Hernández JJ, Álvarez S, Espinet B, Carbonell F. Chronic lymphocytic leukemia with isochromosome 17Q: An aggressive subgroup associated with TP53 mutations and complex karyotypes. Cancer Lett 2017; 409: 42-48. IF 6.375. Q1.

• Gómez-Martin I, Moreno S, Andrades E, Hernández-Muñoz I, Gallardo F, Barranco C, Pujol RM, Segura S. Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin. JAMA Dermatol 2017; 153(8): 771-780. IF 5.817. Q1.

• González-Farré B, Martínez D, López-Guerra M, Xipell M, Monclús E, Rovira J, García F, López-Guillermo A, Colomo L, Campo E, Martínez A. HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma. Modern Pathol 2017; 30(5): 745-760. IF 5.728. D1.

• Colomo L, Vázquez I, Papaleo N, Espinet B, Ferrer A, Franco C, Comerma L, Hernández-Llodrà S, Calvo X, Salar A, Climent F, Mate JL, Forcada P, Mozos A, Nonell L, Martínez A, Carrió A, Costa D, Dlouhy I, Salaverria I, Martín-Subero JI, López-Guillermo A, Valera A, Campo E, Grup per l'Estudi dels Limfomes de Catalunya i Balears (GELCAB). LMO2-negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas. Am J Surg Pathol 2017; 41(7): 877-886. IF 5.363. D1.

• Calvo X, Arenillas L, Luño E, Senent L, Arnan M, Ramos F, Pedro C, Tormo M, Montoro J, Díez-Campelo M, Blanco ML, Arrizabalaga B, Xicoy B, Bonanad S, Jerez A, Nomdedeu M, Ana F, Sanz GF, Florensa L, Grupo Español de Síndromes Mielodisplásicos (GESMD). Enumerating Bone Marrow Blasts from Nonerythroid Cellularity Improves Outcome Prediction in Myelodysplastic Syndromes and Permits a Better Definition of the Intermediate Risk Category of the Revised International Prognostic Scoring System (IPSS-R). Am J Hematol 2017; 92(7): 614-621. IF 5.275. Q1.

• Puiggros A, Collado R, Calasanz MJ, Ortega M, Ruiz-Xivillé N, Rivas-Delgado A, Luño E, González T, Navarro B, García-Malo M, Valiente A, Hernández JA, Ardanaz MT, Piñán MA, Blanco ML, Hernández-Sánchez M, Batlle-López A, Salgado R, Salido M, Ferrer A, Abrisqueta P, Gimeno E, Abella E, Ferrá C, Terol MJ, Ortuño F, Costa D, Moreno C, Carbonell F, Bosch F, Delgado J, Espinet B. Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions. Oncotarget 2017; 8(33): 54297-54303. IF 5.168. Q1.

• García-Colmenero L, Gallardo F, Salar A, Álvarez-Larrán A, Colomo L, Pujol RM. Blastic Plasmacytoid Dendritic Cell Neoplasm Associated with Dystrophic Xanthomatosis after Chemotherapy. Acta Derm-Venereol 2017; 97(2): 293-294. IF 3.653. Q1.

• García-Martínez P, Sitjas D, Llistosella E, Espinet B, Rodríguez M, Hernández-Muñoz I, Gallardo F, Pujol RM. Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosino-philic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. Acta Derm-Venereol 2017; 97(7): 855-857. IF 3.653. Q1.

Ongoing Research Projects

• Desarrollo y validación de un panel de secuenciación para translocaciones y mutaciones con relevancia clínica en neoplasias de células B maduras

- Fondo de Investigación Sanitaria. ISCIII (PI15/00437)

- From 2016 to 2018

- Principal investigator: Espinet Solà, Blanca

 

Group’s Recognitions

• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca Translacional en Neoplàsies Hematològiques (GRETNHE) (2017-2019)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 437)

- Principal researcher: Espinet Solà, Blanca

 

Clinical Trials Signed in 2017

• Estudio fase III, multicéntrico, aleatorizado y abierto con la guadecitabina (SGI-110) en comparación con el tratamiento de elección en adultos con leucemia mieloide aguda tratados previamente

- Register: SGI-110-06

- Principal investigator: Pedro Olivé, Carme

• Estudio observacional prospectivo sobre la supervivencia global y la calidad de vida en pacientes mayores de 60 años diagnosticados de leucemia mieloide aguda en España, tratados según la práctica clínica habitual (estudio SvLMA)

- Register: CEL-LMA-2017-01

- Principal investigator: Pedro Olivé, Carme

 

Theses

• Blanco G. Molecular characterization of the microenvironment in CLL-like monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia. Pompeu Fabra University

- Director: Espinet Solà, Blanca

- Date of defense: 01/12/2017

• Arenillas L. Estrategias de mejora en la evaluación diagnóstica y pronóstica de los síndromes mielodisplásicos. University of Barcelona

- Directors: Florensa L, Solé F

- Date of defense: 14/12/2017

 

 

 

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