Stem Cells and Cancer

Research group

Group Leader

Anna Bigas Salvans

Our research group studies the molecular mechanisms involved in the generation and maintenance of stem cells and their differentiation from functional cells. We particularly focus in studying signaling pathways and their activation effects that control the hematopoietic system. Our goal is to understand how these signals are important in the generation of hematopoietic stem cells during embryonic development, maintenance of these cells in adulthood and how these signals are perturbed in leukemic processes.





Paolo Petazzi (Researcher)

Cristina Porcheri (Researcher)

David Arambilet Morilla (Technician)

Jessica González Miranda (Technician)

Neus Luque Sánchez (Technician)

Irene Pecharroman Ruiz (Technician)

Cristina Ruiz Herguido (Technician)



Main Publications

• Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell 2017; 32(5): 608-623. IF 27.407. D1.

• Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Mol Cell 2017; 68(4): 645-658. IF 14.714. D1.

• Perearnau A, Orlando S, Islam AB, Gallastegui E, Martínez J, Jordan A, Bigas A, Aligué R, Pujol MJ, Bachs O. P27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes. Nucleic Acids Res 2017; 45(9): 5086-5099. IF 10.162. D1.

Ongoing Research Projects

• Regeneració hematopoètica a partir de cèl·lules mare pluripotents

- Departament de Salut, Generalitat de Catalunya (SLT002/16/00299)

- From 2017 to 2019

- Principal investigator: Bigas Salvans, Anna

• Exploring Mechanisms of Resistance in Adult and Pediatric T-Acute Lymphoblastic Leukemia

- Fundación Asociación Española Contra el Cáncer (GC16173697BIGA)

- From 2016 to 2021

- Principal investigator: Bigas Salvans, Anna

• Especificación de célula madre hematopoyética y leucémica

- Ministerio de Economía y Competitividad (SAF2016-75613-R)

- From 2016 to 2019

- Principal investigator: Bigas Salvans, Anna

• Diseccionando el proceso de especificación de células madre hematopoyéticas normales y leucémicas

- Ministerio de Economía y Competitividad (SAF2013-40922-R)

- From 2014-2017

- Principal investigator: Bigas Salvans, Anna


Participation in Research Networks

• CIBER Cancer

- Fondo de Investigación Sanitaria. ISCIII (CB16/12/00244)

- From 2017 to 2018

- Principal investigator: Bigas Salvans, Anna


Group’s Recognitions

• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca en Cèl·lules Mare i Càncer (2017-2019)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 135)

- Principal investigator: Bigas Salvans, Anna



• Colomer C. Unravelling new oncogenic functions of IKKα:towards a better understanding of colorectal carcinogenesis. Pompeu Fabra University.

- Director: Espinosa Blay, Lluis; Bigas Salvans, Anna

- Date of defense: 21/12/2017




C/ Doctor Aiguader, 88

08003 Barcelona

(+34) 93 316 04 00