Musculoskeletal Research
Research group
Group Leader
Francesc Xavier Nogués Solan
Our research focuses on the study of bone disorders and the underlying mechanisms of bone pathophysiology. There are three main lines of investigation in the group: Genetics, epidemiology and bone quality. In the genetic field, we are exploring the genetic basis of bone disorders at population level. In this regard, we have two cohorts, BARCOS and B-ABLE, currently involved in ongoing studies related to bone health. The BARCOS cohort also belongs to the international GEFOS consortium which has performed several genome-wide studies and metanalyses. Moreover, our research also encompasses a number of diseases and therapies that affect bone metabolism as a secondary outcome. Among them, we highlight HIV infection and antiretroviral therapies, atypical fractures and osteonecrosis of the jaw associated with bisphosphonate treatment (the gold standard for osteoporosis), acromegaly, etc. Our group is a leading investigator in the development of a novel, hand-held Reference Point Indentation (RPI) instrument, Osteoprobe®, which measures bone quality. Epidemiological studies using population databases at local and international levels are also developed in our Unit. Along these lines, we are exploring mortality, musculoskeletal and cardiovascular events in women with breast cancer treated with aromatase inhibitors in the SIDIAP database. Finally, our group is also working on the design of biomaterials for promoting the biointegration of implants in osseous and soft tissues.
Members
Elisabeth del Amo Laforga (Researcher)
Adolf Díez Pérez (Researcher)
Leonardo Mellibovsky Saidler (Researcher)
Guillem Saló Bru (Researcher)
Isabel Aymar Fabrega (Technician)
María Lourdes Cos Esquius (Technician)
Guillermina Orduna Erbetta (Technician)
Abora Rial Villavecchia (Technician)
Jaime Rodríguez Morera (Technician)
Main Publications
• Roca-Ayats N, Balcells S, García-Giralt N, Falcó-Mascaró M, Martínez-Gil N, Abril JF, Urreizti R, Dopazo J, Quesada-Gómez JM, Nogués X, Mellibovsky L, Prieto-Alhambra D, Dunford JE, Javaid MK, Russell RG, Grinberg D, Díez-Pérez A. GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. New Engl J Med 2017; 376(18): 1794-1795. IF 72.406. D1.
• Cummings SR, Cosman F, Lewiecki EM, Schousboe JT, Bauer D, Black D, Brown T, Cheung AM, Cody K, Cooper C, Díez-Pérez A, Eastell R, Hadji P, Hosoi T, De Beur SJ, Kagan R, Kiel DP, Reid I, Solomon DH, Randall S. Goal-Directed Treatment for Osteoporosis: A Progress Report from the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis. J Bone Miner Res 2017; 32(1): 3-10. IF 6.284. Q1.
• Herrera S, Pérez-López J, Moltó-Abad M, Güerri-Fernández R, Cabezudo E, Novelli S, Esteve J, Hernández A, Roig I, Solanich X, Prieto-Alhambra D, Nogués X, Díez-Pérez A. Assessment of Bone Health in Patients with Type 1 Gaucher Disease Using Impact Microindentation. J Bone Miner Res 2017; 32(7): 1575-1581. IF 6.284. Q1.
• De Ugarte L, Rodríguez-Sanz M, García-Pérez MA, Olmos JM, Sosa-Henríquez M, Pérez-Cano R, Gómez-Alonso C, del Río L, Mateo-Agudo J, Blázquez-Cabrera JA, González-Macías J, Pino-Montes JD, Muñoz-Torres M, Díaz-Curiel M, Malouf J, Cano A, Pérez-Castrillon JL, Nogués X, García-Giralt N, Díez-Pérez A. SNPs in bone-related miRNAs are associated with the osteoporotic phenotype. Sci Rep 2017; 7(1): 516. IF 4.259. Q1.
• Losada-Grande E, Hawley S, Soldevila B, Martínez-Laguna D, Nogués X, Díez-Pérez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D. Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis. Sci Rep 2017; 7(1): 3781. IF 4.259. Q1.
• Nogués X, Prieto-Alhambra D, Güerri-Fernández R, García-Giralt N, Rodríguez-Morera J, Cos L, Mellibovsky L, Díez-Pérez A. Fracture during oral bisphosphonate therapy is associated with deteriorated bone material strength index. Bone 2017; 103: 64-69. IF 4.14. Q1.
• Güerri-Fernández R, Molina-Morant D, Villar-García J, Herrera S, González-Mena A, Guelar A, Trenchs M, Díez-Pérez A, Knobel H. Bone density, microarchitecture and tissue quality following long-term treatment with tenofovir/emtricitabine or abacavir/lamivudine. JAIDS-J Acq Immun Def Synd 2017; 75(3): 322-327. IF 3.935. Q1.
• Pérez-Sáez MJ, Herrera S, Prieto-Alhambra D, Nogués X, Vera M, Redondo D, Mir M, Güerri-Fernández R, Crespo M, Díez-Pérez A, Pascual J. Bone density, microarchitecture and tissue quality long-term after kidney transplant. Transplantation 2017; 101(6): 1290-1294. IF 3.678. Q1.
Ongoing Research Projects
• Diagnóstico genético de fracturas atípicas de fémur associadas al tratamiento con bisfosfonatos
- FEIOMM (Fundación Española de Investigación Ósea y del Metabolismo Mineral)
- Principal investigator: García Giralt, Natalia
• Estudio para la mejora de la calidad de vida en mujeres con cáncer de mama tratadas con inhibidores de aromatasa: cohorte B-ABLE
- Fondo de Investigación Sanitaria. ISCIII (PI16/00818)
- From 2017 to 2019
- Principal investigator: Nogués Solan, Francesc Xavier
• Determinantes clínicos y genéticos de eventos musculoesqueléticos en mujeres posmenopáusicas tratadas con inhibidores de la aromatasa por cáncer de mama. Cohorte prospectiva B-ABLE
- Fondo de Investigación Sanitaria. ISCIII (PI13/00444)
- From 2014 to 2018
- Principal investigator: Nogués Solan, Francesc Xavier
• Riesgo-beneficio de los bisfosfonatos en los pacientes con osteoporosis e insuficiencia renal
- Fondo de Investigación Sanitaria. ISCIII (ICI14/00248)
- From 2015 to 2017
- Principal investigator: Díez Pérez, Adolf
Participation in Research Networks
• Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad
- Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS (RD12/0043/0022)
- Principal investigator: Diéz Pérez, Adolf
• CIBER Fragilidad y Envejecimiento Saludable
- Fondo de Investigación Sanitaria. ISCIII. CIBER (CB16/10/00245)
- Principal investigator: Diéz Pérez, Adolf
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Unitat de Recerca en Fisiopatologia Òssia i Articular (URFOA). (2017-2019)
- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 502)
- Principal investigator: Nogués Solan, Francesc Xavier
Theses
• Villar-García J. Efecto del tratamiento con probióticos (Saccharomyces Boulardii) sobre el microbioma intestinal y la inflamación sistémica en el paciente VIH virológicamente suprimido. Autonomous University of Barcelona
- Director: Knobel H; Diéz Pérez, Adolf
- Date of defense: 04/07/2017
• Ovejero D. The clinical description, molecular etiology, and pathophysiological studies in cutaneous skeletal hypophosphatemia syndrome: a mosaic disorder of activating RAS mutations. Autonomous University of Barcelona
- Directors: Chico A; Corcoy R; Díez Pérez, Adolf
- Date of defense: 16/06/2017
• Herrera-Fernández S. Evaluación de la afectación ósea en pacientes con enfermedades raras. Autonomous University of Barcelona
- Director: Diéz Pérez, Adolf
- Date of defense: 04/07/2017
• Martínez D. Efecto de la diabetes mellitus tipo 2 sobre la incidencia de fractura osteoporótica. Autonomous University of Barcelona
- Directors: Prieto-Alhambra D; Nogués Solan, Francesc Xavier
- Date of defense: 26/09/2017
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info@imim.es