Integrative Pharmacology and Systems Neuroscience

Research group

Group Leader

Rafael de la Torre Fornell

The group's main line of research is the development of pharmacological and nonpharmacological (cognitive/electrical stimulation) approaches for the treatment of neurodevelopmental and psychiatric disorders (including Down syndrome, drug addiction, depression and schizophrenia). Our emphasis is on understanding the underlying mechanisms of action and on developing biomarkers of exposure, efficacy and toxicity.

Moreover, the Integrated Pharmacology and Systems Neurosciences Research Group is responsible for providing instruction in pharmacology, chemistry and toxicology to graduate and undergraduate students of both human biology and medicine (Pompeu Fabra University, Autonomous University of Barcelona), and training to junior postdoctoral researchers.

Research areas of the group include:

• Pharmacology of psychoactive substances and non-pharmacological cognitive enhancing approaches.

• Development of biomarkers of exposure, efficacy and toxicity.

• Health benefits of nutrition in cognitive performance.

• Neurophysiology and pharmacology of cognition in psychiatric and neurodevelopmental disorders.

• Integrated behavioral pharmacology of mental disorders including drug addiction, schizophrenia and depression.

• Metabolomic approaches in health and disease.

 

2017

Members

Thomas Gener (Researcher)

Àlex Gómez Gómez (Researcher)

Olha Khymenets (Researcher)

José Antonio Pascual Esteban (Researcher)

Óscar Pozo Mendoza (Researcher)

María Victoria Puig Velasco (Researcher)

Gemma Reverter Branchat (Researcher)

Patricia Robledo Montoya (Researcher)

Maria Alemany González (PhD Student)

Anna Boronat Rigol (PhD Student)

Miriam Martínez Huélamo (PhD Student)

Eulàlia Olesti Muñoz (PhD Student)

Carla Ramon Duaso (PhD Student)

Aida Maria Cuenca Royo (Technician)

Cristina Fernández Avilés (Technician)

Jordi García Quintana (Technician)

Cristina Llop Julià (Technician)

Julián Andrés Mateus Rodríguez (Technician)

Iris Lioba Matilla Vaz (Technician)

Esther Menoyo Colomer (Technician)

Pau Nebot Forcada (Technician)

Antoni Pastor Bosch (Technician)
Raul Pérez Ortuño (Technician)

Marta Pérez Otero (Technician)

Nieves Pizarro Lozano (Technician)

Mitona Pujadas Bastardes (Technician)

Laia Roca San José (Research Assistant)

Eva Maria Vitas Gutiérrez (Research Assistant)

 

Main Publications

• De la Torre R, Corella D, Castañer O, Martínez-González MA, Salas-Salvador J, Vila JS, Estruch R, Sorli JV, Arós F, Fiol M, Ros E, Serra-Majem L, Pintó X, Gómez-Gracia E, Lapetra J, Ruiz-Canela M, Basora J, Asensio EM, Covas MI, Fitó M. Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylathion. Am J Clin Nutr 2017; 105(6): 1297-1304. IF 6.926. D1.

• Pérez-Martínez P, Mikhailidis DP, Athyros VG, Bulló M, Couture P, Covas MI, de Koning L, Delgado-Lista J, Díaz-López A, Drevon CA, Estruch R, Espósito K, Fitó M, Garaulet M, Giugliano D, García-Ríos A, Katsiki N, Kolovou G, Lamarche B, Maiorino MI, Mena-Sánchez G, Muñoz-Garach A, Nikolic D, Ordovás JM, Pérez-Jiménez F, Rizzo M, Salas-Salvadó J, Schröder H, Tinahones FJ, de la Torre R, van Ommen B, Wopereis S, Ros E, López-Miranda J. Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation. Nutr Rev 2017; 75(5): 307-326. IF 5.291. D1.

• Pozo O, Pujadas-Bastardes M, Gleeson SB, Mesa-García MD, Pastor A, Kotronoulas A, Fitó M, Covas MI, Navarro JRF, Espejo JA, Sánchez-Rodríguez E, Marchal R, Calleja MA, de la Torre R. Liquid chromatography tandem mass spectrometric determination of triterpenes in human fluids: Evaluation of markers of dietary intake of olive oil and metabolic disposition of oleanolic acid and maslinic acid in humans. Anal Chim Acta 2017; 990: 84-95. IF 4.95. D1.

• Buckland G, Pastor A, Luján-Barroso L, González CA, Travier N, Amiano P, Huerta JM, Agudo A, Navarro C, Chirlaque MD, Sánchez MJ, Rodríguez-Barranco M, Barricarte A, Ardanaz E, Dorronsoro M, Molinuevo A, Quirós JR, de la Torre R. Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study. Mol Nutr Food Res 2017; 61(8): 1600927. IF 4.323. D1.

• Goday A, Farré M, Rodríguez-Morató J, Ramon-Moros JM, Pérez-Mañá C, Papaseit E, Civit E, Langohr K, Carbó M, Benaiges D, Castañer O, Flores JA, Pera MR, Grande L, de la Torre R. Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism. Obes Surg 2017; 27(12): 3194-3201. IF 3.947. D1.

• Kotronoulas A, Gómez-Gómez A, Segura J, Ventura R, Joglar J, Pozo O. Evaluation of two glucuronides resistant to enzymatic hydrolysis as markers of testosterone oral administration. J Steroid Biochem & Mol Biol 2017; 165(Pt B): 212-218. IF 4.561. Q1.

• Robles J, Marcos J, Renau N, Garrostas L, Segura J, Ventura R, Barceló B, Barceló A, Pozo O. Quantifying endogenous androgens, estrogens, pregnenolone and progesterone metabolites in human urine by gas chromatography tandem mass spectrometry. Talanta 2017; 169: 20-29. IF 4.162. Q1.

Ongoing Research Projects

• Caracterització dels determinants genètics dels fenotips de neuroimatge associats a la malaltia d’Alzheimer en participants de la cohort ALFA

- Departament de Salut, Generalitat de Catalunya (SLT002/16/00201)

- From 2017 to 2019

- Principal investigator: De la Torre Fornell, Rafael

• Desarrollo de nuevos conjugados de ácidos grasos para el tratamiento de las esteatohepatitis

- Fondo de Investigación Sanitaria. ISCIII (DTS16/00035)

- From 2017 to 2018

- Principal investigator: De la Torre Fornell, Rafael

• Role of serotonin in the rescuing effects of cognitive therapies: in vivo study of neural network dynamics in mouse models of Down syndrome and schizophrenia

- Ministerio de Economía y Competividad SAF2016-80726-R

- From 2016 to 2019

- Principal investigator: Puig Velasco, María Victoria

• Medida de biomarcadores específicos del uso de cigarrillos electrónicos (propilenglicol), y tabaco (nicotina, carcinógenos) en una cohorte de usuarios de cigarrillos electrónicos

- Fondo de Investigación Sanitaria. ISCIII (PI15/00434)

- From 2016 to 2018.

- Principal investigator: Pascual Esteban, José Antonio

• Neural activity patterns of cognitive normalization mediated by environmental enrichment and epigallocatechin-3-gallate in a murine model of Down síndrome

- Fondation Jérôme Lejeune

- From 2016 to 2018

- Principal investigator: Puig Velasco, María Victoria

• Evaluation of dose and source of green tea extracts as contributing factors to treatment efficacy and hepatotoxicity. Therapeutic implications in Down síndrome

- Fondation Jérôme Lejeune

- From 2016 to 2018

- Principal investigator: Pizarro Lozano, Nieves

• Neural Substrates of Atypical Antipsychotic Drug Action: Role of Serotonin 5-HT1A and 5-HT2A Receptors in Neural Network Dynamics in the Mouse Prefrontal Cortex and Hippocampus during Executive Function

- Brain & Behavior Research Foundation (23014)

- From 2015 to 2018

- Principal investigator: Puig Velasco, María Victoria

• Characterization of novel suppressors of neurodegeneration in myotonic dystrophy type 1 (DM1)

- Fundació La Marató de TV3 (20143530)

- From 2015 to 2018

- Principal investigator: Robledo Montoya, Patricia

• Predicting Risk of Emerging Drugs with In silico and Clinical Toxicology (PREDICT)

- European Commission (HOME/2014/JDRU/AG/DRUG/7082)

- From 2016 to 2017

- Principal investigator: De la Torre Fornell, Rafael

• BIs-Conjugates in the Endogenous Profile of Steroids (BICEPS)

- World Anti-doping Agency (15A29OP)

- From 2016 to 2018

- Principal investigator: Pozo Mendoza, Óscar

• Immunorecognition of specific markers of blood storage. Customization and testing of already developed antibodies

- World Anti-doping Agency (ISF16M04JP)

- From 2016 to 2017

- Principal investigator: Pascual Esteban, José Antonio

• El consumo moderado de vino promueve la generación endógena del antioxidante natural hidroxitirosol. Implicaciones en la prevención de enfermedades cardiovasculares

- Fondo de Investigación Sanitaria. ISCIII (PI14/00072)

- From 2015 to 2018

- Principal investigator: De la Torre Fornell, Rafael

• Implicación de los heterómeros CB1-5-HT2A en las alteraciones cognitivas y conductuales de la esquizofrenia y su interacción con el consumo de cannabis: un enfoque traslacional

- Fondo de Investigación Sanitaria. ISCIII (PI14/00210)

- From 2015 to 2018

- Principal investigator: Robledo Montoya, Patricia

• Remodelando el desarrollo cerebral: potenciación de la plasticidad neuronal para mejorar el rendimiento cognitivo en síndromes que causan discapacidad intelectual

- Fundación Mutua Madrileña (AP157312015)

- From 2015 to 2018.

- Principal investigator: De la Torre Fornell, Rafael

• Screening of testosterone misuse by metabolites resistant to enzymatic hydrolysis

- World Anti-doping Agency (14A29OP)

- From 2015 to 2017

- Principal investigator: Pozo Mendoza, Óscar

• Estudio metabolómico en pacientes con Porfiria Aguda Intermitente: caracterización de los desajustes hormonales y catabólicos asociados a la enfermedad y efectos del tratamiento con hemina

- Fondo de Investigación Sanitaria. ISCIII (PI14/00147)

- From 2015 to 2018

- Principal investigator: Pozo Mendoza, Óscar

• Developments for improving compliance with blood testing, a fundamental but minimally implemented tool in doping control (EASY BLOOD)

- International Olympic Committee

- From 2015 to 2017

- Principal investigator: Segura Noguera, Jordi

• Recombinant hGH Biomarkers Discovery, Phase II

- World Anti-Doping Agency (T13M07RD)

- From 2014 to 2017

- Principal investigator: De la Torre Fornell, Rafael

 

Participation in Research Networks

• Centro de Investigación Biomédica en Red

- Fisiopatología de la Obesidad y Nutrición (CIBERobn) (CB06/03/0028)

- Collaborating investigators: De la Torre Fornell, Rafael; Pastor Bosch, Antoni; Pujadas Bastardes, Mitona; Rodríguez-Morató, Josep

- Principal investigator: Fitó Colomer, Montse

• Red de Trastornos Adictivos (RTA)

- RD06/0001/1009

- Collaborating investigator: Robledo Montoya, Patricia

- Principal investigator: Torrens Melich, Marta

 

Group’s Recognitions

• Officially recognized as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca Clínica en Farmacologia, i Desenvolupament de Biomarcadors i Nous Fàrmacs (2017-2019)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 138)

- Principal investigator: De la Torre Fornell, Rafael

• Officially recognized as a emerging research group by the Generalitat de Catalunya: Grup de Recerca en Neuroquímica i Neurofisiologia de la Cognició en Malalties Psiquiàtriques i del Desenvolupament (2017-2019)

- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 210)

- Principal investigator: Puig Velasco, María Victoria

• The group has obtained the renewal as center TECNIO BAPP (Technological Innovation Network) of ACC1Ó

- Director: De la Torre Fornell, Rafael

 

Clinical Trials Signed in 2017

• Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS)

- Register: PERSEUS/1

- Principal investigator: De la Torre Fornell, Rafael

 

Other

• Best International Senior Publication (2014)

- Agency for Health Quality and Assessment of Catalonia (AQuAS, as per the acronym in Catalan)

• Full Member Royal Academy of Pharmacy (Rafael de la Torre)

 

 

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info@imim.es