Epithelial-Mesenchymal Transition in Tumor Development
Research group
Group Leader
Antonio García de Herreros Madueño
The group is oriented towards the study of the mechanisms controlling the acquisition of invasiveness by epithelial tumors as the first step in tumor metastasis. More specifically we study the role of E-cadherin and E-cadherin-associated proteins in this process. We focus in the relevance of epithelial-to-mesenchymal transition (EMT) in tumor invasion as well as the co-adjuvant role of cancer-associated fibroblasts. The group is especially interested in the role of Snail1 transcriptional factor required for EMT and also for fibroblast activation. Using fibroblast deprived in this transcriptional factor as control, we use the effect of the tumoral stroma in the growth, invasion and vascularization of epithelial tumors. We are also interested in the Snail1-dependent molecular pathways in fibroblasts involved in the activation of tumor cell invasion.
Members
Josep Baulida Estadella (Researcher)
Víctor Manuel Díaz Cortés (Researcher)
Rocco Mazzolini (Researcher)
David Cabrerizo Granados (PhD Student)
Héctor Franco Valls (PhD Student)
Guillem Lambies Barjau (PhD Student)
Aida Mestre Farrera (PhD Student)
Rubén Olivera Salguero (PhD Student)
Gemma Serra Bardenys (PhD Student)
Raul Peña Arranz (Technician)
Laura Sala Romanyà (Technician)
Jordi Vergés Sanjaime (Technician)
Aida Villarroel Vargas (Technician)
Main Publications
• Vinyoles M, del Valle-Pérez B, Curto J, Padilla M, Villarroel A, Yang J, García de Herreros A, Duñach M. Activation of CK1ε by PP2A/PR61ε is required for the initiation of Wnt signaling. Oncogene 2017; 36(3): 429-438. IF 7.519. D1.
• Duñach M, del Valle-Pérez B, García de Herreros A. P120-catenin in canonical Wnt signaling. Crit Rev Biochem Mol 2017; 52(3): 327-339. IF 6.639. Q1.
• Baulida J. Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts. Mol Oncol 2017; 11(7): 847-859. IF 5.314. Q1.
• Moustakas A, García de Herreros A. Epithelial-mesenchymal transition in cancer (Editorial). Mol Oncol 2017; 11: 715-717. IF 5.314. Q1.
• Prunotto M, Chaykovska L, Bongiovanni M, Frattini M, Cagarelli T, Weibel F, Bruschi M, García de Herreros A, Moll S. Tubular Cytoplasmic Expression of SNAI1 in Renal Transplant Biopsies: A Sign of Diseased Epithelial Phenotype?. Am J Pathol 2017; 187(1): 55-69. IF 4.057. Q1.
Ongoing Research Projects
• Entendiendo el papel de Snail1 en la metástasis: análisis de la acción de los fibroblastos activos
- Ministerio de Economía y Competitividad (SAF2016-76461-R)
- From 2017 to 2019
- Principal investigator: García de Herreros Madueño, Antonio
• Caracterización de dianas funcionales e inhibidores de la actividad miofibroblástica para frenar la formación de metástasis
- Fondo de Investigación Sanitaria. ISCIII (PI15/00447)
- From 2016 to 2018
- Principal investigator: Baulida Estadella, Josep
Participation in Research Networks
• Thematic network cooperative research on cancer (RTICC)
- Fondo de Investigación Sanitaria. ISCIII Subprogram RETICS. RD12/0036/0005
- Principal investigator: García de Herreros Madueño, Antonio
Group’s Recognitions
• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca en Transició Epiteli-Mesènquima i Invasió Tumoral (2017 to 2019)
- Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 24)
- Principal investigator: García de Herreros Madueño, Antonio
Theses
• González N. Snail1 controls telomere integrity and transcription and telomerase expression. Pompeu Fabra University
- Director: García de Herreros Madueño, Antonio; Canudas, S
- Date of defense: 18/09/2017
C/ Doctor Aiguader, 88
08003 Barcelona
(+34) 93 316 04 00
info@imim.es