Translational Research on Hematological Neoplasms

Research group

Group Leader

Lourdes Florensa Brichs
(Group Leader until November 2016)

Blanca Espinet Solà
(Group Leader from November 2016)

The Translational Research on Hematological Neoplasms Group (GRETNHE) is integrated within the Cancer Programme from the Hospital del Mar Medical Research Institute (IMIM). The GRETNHE is a multidisciplinary group with different research areas. Among them, the most relevant are myelodysplastic syndromes (MDS), myeloproliferative neoplasms/myelodysplastic syndromes (MPN/MDS), chronic lymphocytic leukemia/monoclonal B cell lymphocytosis (CLL/MBL), mantle cell lymphoma/monoclonal asymptomatic lymphocytosis cyclin D1 positive (MCL/MALD1), splenic marginal zone lymphoma (SMZL) and cutaneous lymphomas (CL). Our aim is the phenotypic, cytogenetic and molecular characterization of these entities.

Members

Leonor Arenillas Rocha (Researcher)

Luis Carlos Barranco Sanz (Researcher)

Gonzalo Blanco Ares (PhD Student)

Sergi Clavé Safont (Technician)

Lluís Colomo Saperas (Researcher)

Beatriz Costán Medina (Technician)

Ana Ferrer del Álamo (Researcher)

Fernando Gallardo Hernández (Researcher)

Belén Lloveras Rubio (Researcher)

M. Carme Melero Vilella (Technician)

Carme Pedro Olivé (Researcher)

Anna Maria Puiggros Metje (Researcher)

Clea Renard Marine (Technician)

Maria del Mar Rodríguez Rivera (Technician)

Marta Salido Galeote (Researcher)

 

more info

Main Publications

• Arenillas L, Calvo X, Luño E, Senent L, Alonso E, Ramos F, Ardanaz MT, Pedro C, Tormo M, Marco V, Montoro J, Diez-Campelo M, Brunet S, Arrizabalaga B, Xicoy B, Andreu R, Bonanad S, Jerez A, Nomdedeu B, Ferrer A, Sanz GF, Florensa L. Considering Bone Marrow Blasts From Nonerythroid Cellularity Improves the Prognostic Evaluation of Myelodysplastic Syndromes. J Clin Oncol 2016; 34(27): 3284-3292. IF 20.982. Q1.

• Baliakas P, Puiggros A, Xochelli A, Sutton LA, Nguyen-Khac F, Gardiner A, Plevova K, Minga E, Hadzidimitriou A, Walewska R, McCarthy H, Ortega M, Collado R, González T, Granada I, Luño E, Kotašková J, Moysiadis T, Davis Z, Stavroyianni N, Anagnostopoulos A, Strefford JC, Pospisilova S, Davi F, Athanasiadou A, Rosenquist R, Oscier D, Espinet B, Stamatopoulos K. Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. Haematologica 2016; 101(7): e299-e302. IF 6.671. Q1.

• Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R, Xochelli A, Rodríguez-Rivera M, Ortega M, Calasanz MJ, Luño E, Vargas M, Grau J, Martínez-Laperche C, Valiente A, Cervera J, Anagnostopoulos A, Gimeno E, Abella E, Stalika E, Hernández-Rivas JM, Ortuño FJ, Robles D, Ferrer A, Ivars D, González M, Bosch F, Abrisqueta P, Stamatopoulos K, Espinet B. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget 2016; 7(49): 80916-80924. IF 5.008. Q1.

• Calvo X, Arenillas L, Luño E, Senent L, Arnan M, Ramos F, Ardanaz MT, Pedro C, Tormo M, Montoro J, Diez-Campelo M, Arrizabalaga B, Xicoy B, Bonanad S, Jerez A, Nomdedeu B, Ferrer A, Sanz GF, Florensa L, and on behalf of Grupo Español de Síndromes Mielodisplásicos (GESMD). Erythroleukemia shares biological features and outcome with myelodysplastic syndromes with excess blasts: a rationale for its inclusion into future classifications of myelodysplastic syndromes. Modern Pathol 2016; 29(12): 1541-1551. IF 5.485. Q1.

• Hastings RJ, Bown N, Tibiletti MG, Debiec-Rychter M, Vanni R, Espinet B, van Roy N, Roberts P, van den Berg-de-Ruiter E, Bernheim A, Schoumans J, Chatters S, Zemanova Z, Stevens-Kroef M, Simons A, Heim S, Salido M, Ylstra B, Betts DR. Guidelines for cytogenetic investigations in tumours. Eur J Hum Genet 2016; 24(1): 6-13. IF 4.58. Q1.

• Prasad A, Rabionet R, Espinet B, Zapata L, Puiggros A, Melero C, Puig A, Sarria-Trujillo Y, Ossowski S, García-Muret MP, Estrach T, Servitje O, López-Lerma I, Gallardo F, Pujol RM, Estivill X. Identification of gene mutations and fusion genes in patients with Sézary Syndrome. J Invest Dermatol 2016; 136(7): 1490-1499. IF 6.915. Q1.

• Rovira J, Karube K, Valera A, Colomer D, Enjuanes A, Colomo L, Martínez-Trillos A, Giné E, Dlouhy I, Magnano L, Delgado J, Martínez A, Villamor N, Campo E, López-Guillermo A. MYD88 L265P mutations, but no other variants, identify a subpopulation of DLBCL patients of activated B-cell origin, extranodal involvement and poor outcome. Clin Cancer Res 2016; 22(11): 2755-2764. IF 8.738. Q1.

• Valera A, Epistolio S, Colomo L, Riva A, Balagué O, Dlouhy I, Tzankov A, Bühler M, Haralambieva E, Campo E, Soldini D, Mazzucchelli L, Martín V. Definition of MYC genetic heteroclonality in diffuse large B-cell lymphoma with 8q24 rearrangement and its impact on protein expression. Modern Pathol 2016; 29(8): 844-853. IF 5.485. Q1.

Ongoing Research Projects

• Development and validation of a NGS panel to detect translocations and mutations with clinical relevance in mature B-cell neoplasms

− Fondo de Investigación Sanitaria. ISCIII (PI15/00437)

− From 2016 to 2018

− Principal investigator: Espinet Solà, Blanca

 

• Biologic characterization of B-cells, T-cells and NK-cells of monoclonal B cell lymphocytosis with a CLL phenotype

− Fondo de Investigación Sanitaria. ISCIII (PI11/01621)

− From 2012 to 2016

− Principal investigator: Espinet Solà, Blanca

Participation in Research Networks

• RETICS 2012 subprogram.

− Fondo de Investigación Sanitaria. RTICC, RD12/0036/0044

− Principal investigator: Solé Ristol, Francesc

• Spanish Society of Hematology and Hemotherapy (SEHH)

• Spanish Cooperative Group of Hematological Cytogenetics (GCECGH)

• Spanish Group of Hematological Cytology (GECH)

• Spanish Group of Chronic Lymphocytic Leukemia (GELLC)

• Spanish Group of Myelodysplastic Syndromes (GESMD)

• Spanish Association of Human Genetics (AEGH)

• Lymphoma Group of the Spanish Association of Dermatology and Venereology (AEDV)

• European Cytogeneticists Association (ECA)

• Splenic B-cell Lymphoma Group (SBLG)

• Cytogenetic European Quality Assessment (CEQA), Mature B&T Cell Neoplasms

• European Research Initiative on CLL (ERIC)

Group’s Recognitions

• Officially recognised as a consolidated research group by the Generalitat de Catalunya: Grup de Recerca Translacional en Neoplàsies Hematològiques (GRETNHE) (2014-2017)

− Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 585)

− Principal investigator: Espinet Solà, Blanca

Clinical Trials Signed in 2016

• Estudio de Fase 2/3, multicéntrico, aleatorizado, abierto, de tres grupos y dos etapas, de ASP2215 (Gilteritinib), la combinación de ASP2215 más azacitidina y azacitidina sola en el tratamiento de pacientes con leucemia mieloide aguda de diagnóstico reciente con mutación de FLT3 no elegibles para quimioterapia de inducción intensiva

− Register: 2215-CL-0201

− Principal investigator: Pedro Olivé, Carme

 

• Estudio de fase III, doble ciego, controlado con placebo de quizartinib (AC220) administrado en combinación con quimioterapia de inducción y consolidación, y administrado como terapia de mantenimiento a sujetos de 18 a 75 años con leucemia mielógena aguda FLT3ITD (+) de nuevo diagnóstico (QuANTUM-First)

− Register: AC220-A-U302

− Principal investigator: Pedro Olivé, Carme

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08003 Barcelona

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info@imim.es