Group Leader

Jaume Roquer González

This is a clinical group involved in stroke research. Currently our group is included in the Red de Investigación Cardiovascular (RIC) that is one of the main Spanish research networks. The strengths of our group are: first, our ongoing database named BASICMAR, that contains extensive demographic, epidemiological, clinical, and outcome data about all stroke patients (n=6,400) admitted to our hospital, and second, our large collection of blood sample of stroke patients for genetic and biomarkers studies (n=4,500). The two main research lines are:

1. Clinical research and biomarkers in stroke: epidemiology, natural history and vascular risk factors, stroke biomarkers, diet and stroke, neurosonology and neuro-imaging.

2. Genetic and stroke research: our unit is part of the International Stroke Genetics Consortium, which includes many international (USA, Europe) and national groups and of the GENESTROKE Consortium working to develop GWAS and EWAS studies and projects.

Members

Elisa Cuadrado Godia (PhD Student)

Eva Giralt Steinhauer (Researcher)

Alejandra Gómez González (Technician)

Jordi Jiménez Conde (Researcher)

Marina Mola Caminal (Technician)

Ángel Javier Ois Santiago (Researcher)

Albert Puig Pijoan (Technician)

Ana María Rodríguez Campello (Researcher)

Gemma Romeral Ballester (Researcher)

Miguel Ángel Rubio Pérez (Technician)

Carolina Soriano Tárraga (Researcher)

Rosa Maria Vivanco Hidalgo (Technician)

 

more info

Main Publications

• Anderson C, Falcone G, Chia-Ling P; Radmanesh F, Brouwers H, Battey T, Biffi A, Peloso G, Liu D, Ayres A, Goldstein J. Viswanathan A, Greenberg S, Selim M, Meschia J, Brown D, Worrall B, Silliman Scott, Tirschwell D, Flaherty M, Kraft P, Jagiella J, Schmidt H, Hansen B, Jiménez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tárraga C; van Nieuwenhuizen K, Klijn C, Rannikmae K, Samarasekera N, Al-Shahi Salman R, Sudlow C, Deary I Morotti A, Pezzini A, Pera J, Urbanik A, Pichler A, Enzinger C, Norrving B, Montaner J, Fernández-Cadenas I, Delgado P, Roquer J, Lindgren A, Slowik A, Schmidt R, Kidwell C, Kittner S, Waddy S, Langefeld C, Abecasis G, Willer C, Kathiresan S, Woo D, Rosand J. Genetic Variants in CETP Increase Risk of Intracerebral Hemorrhage. Ann Neurol 2016; 80: 730-740. IF 9.683. Q1.

• Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauza C, Soriano-Tárraga C, Giralt-Steinhauer E, Mola M, Díaz-Navarro R, Tur S, Muiño E, Gallego-Fábrega C, Beltrán S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Malik R, Worrall B, Seshadri S, Montaner J, Fernández-Cadenas I. Whole exome sequence analysis reveals TRPV3 as a possible new risk factor for cardioembolic stroke. Thromb Haemost 2016; 116: 1165-1171. IF 5.255. Q1.

• Johansson E, Cuadrado E, Hayden D, Bjellerup J, Ois A, Roquer J, Wester P, Kelly PJ. Recurrent stroke in symptomatic carotid stenosis awaiting revascularization: A pooled analysis. Neurology 2016; 86(6): 498-504. IF 8.166. Q1.

• Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.; Stroke Genetics Network (SiGN).; International Stroke Genetics Consortium (ISGC) (...Jiménez-Conde J...). Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 2016; 15: 695-707. IF 23.46. Q1.

• NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC) (...Cuadrado Godia E, Jiménez-Conde J, Giralt Steinhauer E, Mola Caminal M, Ois A, Roquer J, Rodríguez-Campello A...). Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol 2016; 15: 174-184. IF 23.46. Q1.

• Ntaios G, Vemmos K, Lip GY, Koroboki E, Manios E, Vemmou A, Rodríguez-Campello A, Cuadrado E, Giralt E, Arnao V, Caso V, Paciaroni M, Díez-Tejedor E, Fuentes B, Pérez-Lucas J, Arauz A, Ameriso SF, Hawkes MA, Pertierra L, Gómez-Schneider M, Bandini F, Chavarria-Cano B, Iglesias AM, García-Pastor A, Gil-Núñez A, Putaala J, Tatlisumak T, Barboza MA, Athanasakis G, Makaritsis K, Papavasileiou V. Risk Stratification for Recurrence and Mortality in Embolic Stroke of Undetermined Source. Stroke 2016; 47(9): 2278-2285. IF 5.787. Q1.

• Pérez de la Ossa N, Abilleira S, Dorado L, Urra X, Ribó M, Cardona P, Giralt E, Martí-Fàbregas J, Purroy F, Serena J, Cánovas D, Garcés M, Krupinski J, Pellisé A, Saura J, Molina C, Dávalos A, Gallofré M, Catalan Stroke Code and Reperfusion Consortium (...Roquer J, Rodríguez-Campello A, Ois A, Jiménez-Conde J...). Access to Endovascular Treatment in Remote Areas: Analysis of the Reperfusion Treatment Registry of Catalonia. Stroke 2016; 47(5): 1381-1384. IF 5.787. Q1.

• Prats-Sánchez L, Camps-Renom P, Sotoca-Fernández J, Delgado-Mederos R, Martínez-Domeño A, Marín R, Almendrote M, Dorado L, Gomis M, Codas J, Llull L, Gómez-González A, Roquer J, Purroy F, Gómez-Choco M, Cánovas D, Cocho D, Garcés M, Abilleira S, Martí-Fàbregas J, on behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). Remote Intracerebral Hemorrhage After Intravenous Thrombolysis: Results From a Multicenter Study. Stroke 2016; 47(8): 2003-2009. IF 5.787. Q1.

• Roquer J, Rodríguez-Campello A, Jiménez-Conde J, Cuadrado E, Giralt E, Vivanco R, Soriano C, Ois A. Sex-related differences in primary intracerebral hemorrhage. Neurology 2016; 87(3): 257-262. IF 8.166. Q1.

• Sayols-Baixeras S, Subirana I, Lluís-Ganella C, Civeira F, Roquer J, Do AN, Absher D, Muñoz D, Soriano-Tárraga C, Jiménez-Conde J, Ordovas J, Sentí M, Aslibekyan S, Marrugat J, Arnett DK, Elosua R. Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study. Hum Mol Gen 2016; 25: 4556-4565. IF 5.985. Q1.

• Soriano C, Jiménez-Conde J, Giralt E, Mola M, Vivanco R, Ois A, Rodríguez-Campello A, Cuadrado E, Sayols-Baixeras S, Elosua R, Roquer J, on behalf of the GENESTROKE Consortium. Epigenome-wide association study identifies TXNIP gene associated with Type 2 diabetes mellitus and sustained hyperglycemia. Hum Mol Genet 2016; 25(3): 609-619. IF 5.985. Q1.

• Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw JM, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, On behalf of the International Stroke Genetics Consortium (...Soriano C, Roquer J, Jiménez-Conde J...). Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology 2016; 86(2): 146-153. IF 8.166. Q1.

Ongoing Research Projects

• MENEAS: MEthylation of DNA depending on Nutrition and Exercise habits. Developing a marker of “biologicalAge” andrisk of Stroke

− Recercaixa JJ086116

− From 2014 to 2016

− Principal investigator: Jiménez Conde, Jordi

 

• Impacto de la polución ambiental aérea (carbón negro y material particulado) en el ictus isquémico

− Fondo de Investigación Sanitaria. ISCIII (PI15/00445)

− From 2016 to 2018

− Principal investigator: Roquer González, Jaume

 

• Estudio de Epigenome Wide Association en Leucoaraiosis. Contribución de la epigenética en el envejecimiento cerebral. International Stroke Genetic Consortium (ISGC)

− Fondo de Investigación Sanitaria. ISCIII (PI15/00451)

− From 2016 to 2018

− Principal investigator: Jiménez Conde, Jordi

Participation in Research Networks

• Red Cardiovascular

− Fondo de Investigación Sanitaria. ISCIII. Subprograma RETICS. RD12/0042/0020

− Principal investigator: Roquer González, Jaume

Group’s Recognitions

• Officially recognized as a consolidated research group the Generalitat de Catalunya: Grup de Recerca Neurovascular (NEUVAS) (2014-2017)

− Agència de Gestió d’Ajuts Universitaris i de Recerca (SGR 1213)

− Principal investigator: Roquer González, Jaume

Clinical Trials Signed in 2016

• Estudio de búsqueda de dosis, multicéntrico, doble ciego, controlado con placebo, aleatorizado y de grupos paralelos, para evaluar la seguridad y la eficacia de natalizumab intravenoso (BG00002) en el accidente cerebrovascular isquémico agudo

− Register: 101SK202

− Principal investigator: Roquer González, Jaume

 

• Ensayo aleatorizado de eficacia y seguridad con S44819 oral tras un accidente isquémico cerebral reciente. Estudio de fase II internacional, multicéntrico, aleatorizado, doble ciego y controlado frente a placebo

− Register: CL2-44819-004

− Principal investigator: Roquer González, Jaume

 

• Ensayo clínico para investigar los beneficios clínicos y organizativos del SRA, una nueva tecnología en la detección de fibrilación auricular como factor etiológico en pacientes ingresados en la Unidad de Ictus con un accidente cerebrovascular o un ataque isquémico transitorio

− Register: SRA

− Principal investigator: Rodríguez Campello, Ana María

 

• Ensayo doble ciego, de grupos paralelos, de la eficacia y la seguridad a largo plazo de MK 8931 (SCH 900931) en sujetos con deterioro cognitivo leve amnésico por enfermedad de Alzheimer (EA prodrómica). Este ensayo a largo plazo es una extensión del ensayo de 104 semanas inicial.

− Register: 8931-019-07

− Principal reseracher: Puig Pijoan, Albert

 

• Estudio comparando el traslado de pacientes con ictus agudo y sospecha de oclusión de gran vaso cerebral al Centro Local de Ictus más cercano vs traslado directo a un Centro Endovascular en el territorio catalán

− Register: RECECAT

− Principal investigator: Rodríguez Campello, Ana María

 

• Estudio aleatorizado, doble ciego, controlado con placebo y de comienzo aplazado de LY3314814 en la demencia de la enfermedad de Alzheimer leve (estudio DAYBREAK)

− Register: I8D-MC-AZET

− Principal reseracher: Puig Pijoan, Albert

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