Effect og ischemia/reperfusion lesion over liver micrometastasis of colorectal cancer growing

Resection is the treatment of choice of the liver metastases. However, most of hepatectomies are carried out under intermittent vascular occlusion of the hepatic hilum (maneuver of Pringle) with the consequent injury for ischemia/reperfusion in the hepatic tissue. The hypothesis to test is that the maneuvers of intermittent occlusion of the hepatic hilum or manoeuvre of Pringle provoke an acceleration of the growth of the hepatic micrometastases proved by a decrease of the spare time of illness.

Methodology: Prospective, randomized, simple blind study of a consecutive sequence of 78 hepatic resections because liver metastasis from colorectal cancer with a minimum follow-up of two years. There will be two groups, control and study. In the control group hepatic resection will be made with the necessary hiliar occlusion, as usual. Patients without hiliar occlusion will form the study group during the resection. Blood, liver tissue and lymph node samples were remove for study.